(I take 50mg Zoloft in the morning and 0.5 mg Flunitrazepam at night). I've searched the net but all I could find was that the combination of Zoloft and other CNS active drugs hasn't been studied. I know that I should trust my GP but as I understand Flunitrazepam is pretty strong which is a little scary. Hello rawboots. When I was on zoloft I'd take it late afternoon, early evening. Reason being, since it made me tired to begin with, it would help me to fall asleep. Many people take Zoloft in the morning and during the start up stage, they just bear through the fatigue. I do know of some people who take it right before bed too, and that seems to work for them. I do know of some people who take it right before bed too, and that seems to work for them. Hi, to some extent the time of day you take a/d drugs is down to personal preference. Try taking it at night and see how you feel. I take 2 different anti-depressants, one in the morning and one in the evening before bed as that one makes me sleepy. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Kumar on zoloft morning or night: Start it in the AM if it makes you drowsy take it at nite with your seroquel (quetiapine). Usually at night. Usually zoloft is calming and facilitates sleep even though it isn't a sleep aid. But a minority of people feel more awake and can't sleep after taking it. I always take mine in the morning after breakfast (I was advised to in case they upset my stomach, but actually it's fine). Then I know that's done and I can forget about it for the rest of the day. Determining if you should take your antidepressant at night or in the morning depends on the specific medication you're taking, its side effects, and how it influences your quality of life. im taking 50 mills of zoloft a day half in the morning half at night my question is if i take half in the morning can i take the other half late afternoon instead of nightime Read More The doctor switched me to Zoloft and the night sweats have continued.